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Sunday, May 16, 2010

Research finds new genes that play role in Alzheimer's

WASHINGTON (AFP) – US and Europeanfill in the blanks researchers have identified two new genes that may play a role in the development of Alzheimer's disease and could help unravel new treatments, a study published Tuesday said.Researchers have now uncovered nine genes they believe are involved inout of your control the development of Alzheimer's Disease (AD), according to a study published in the May 12 issue of the Journal of the American Medical Association."Identifying each of these new genes... points to new biological pathways involved in the development of AD,"Beauty is Meaningless said senior author Sudha Seshadri, an associate professor of neurology at the Boston University School of Medicine."Although such benefits are likely a decade away, studying these pathways should lead to new ways to postpone, prevent and perhaps treat the disease."a world in a grain of sand
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enough on the subsidies in the bill kneel only to Godthat help people to buy insurance. "Most people want coverage. People shouldn't focus so much on what the rules are in terms of making you get coverage," she said. "I thinkJust have a little faith the good news for most people is they'll be able finally to have some choices, some ability to really control their own health decisions, and some help paying for it. It's really one of the biggest middle-class tax cuts for health care that's ever been put input all this behind us place in the history of the country."The health-care law's potential price tag went up today, when the Congressional Budget Office released a new estimate forecasting an additional $115 billion in discretionary spending over the next decade. The CBO had earlier set that cost at $778 billion over the next 10 years. And, with corresponding revenues and cost reductions factored in, the agency said the reform measure would reduce the deficit by $138 billion over the same time period. The new figures wipe out much of that deficit reduction and bring the total price above the politically sensitive trillion-dollar barrier. Sebelius said she hadn't seen the new CBO figures but that the new projected spending wasn't part of the bill's "core."There's lots of discretionary funding," she said. "So if funding is made available for this programShe is the love of my life or that program a€” there are lots of ideas in the bill that aren't really priced out. And I think that will be on a case-by-case basis. When Congress feels that there are appropriate dollars to spend, they'll allocate them. But that really isn't in the core package of the bill."Even though it is the law of the land, health-care reform continues to face fierce resistance the first time in my lifefrom some quarters — 22 states have either filed or threatened to file lawsuits claiming that the insurance mandate is unconstitutional. Some GOP senators have indicated that the issue will come up in Supreme Court nominee Elena Kagan's confirmation hearings — a prospect that Sebelius says won't yield much substantive discussion. "It's unlikely that she or any other nominee would engage in a real discussion" on an issue that could come before the court, Sebelius said, but she's confident that the mandate passes constitutional muster and dismisses the lawsuits as political maneuvers.
"I know that there have been some challenges by attorneys general — most of whom are actually candidates for some higher office — and I think it's not unlikely that this has as much to do with politics as it does with constitutional law," Sebelius said. "But we're going to move ahead and implement the strategies of the plan. And there's a lot of good news available for Americans, including the policy we rolled out today."http://forum.sarmaye.com
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Sunday, March 7, 2010

MANAGERIAL

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Wednesday, February 3, 2010

Credit card interest

Oh, NFBSK the credit card companies. Call the WAMBULANCE, we aren't getting to loan shark everyone with impunity anymore, wah wah poor us now we have to make up for it by screwing everyone somewhere else.

They gutted CC regulation some years back which permitted them to all be based in states that basically allow loan sharking (I think it's South Dakota, not sure, but you can tell because all your CC's are out of there and it's the congressmen from those states voting against it) and suddenly they can't keep afloat unless they charge you a 40 dollar fee every time you turn around and raise interest rates to 29 percent. Before they did that, before that change in regulation, they didn't do all this crap they do now, and they seemed to do just fine. And people who deserved credit could get it just fine.

Now that they are finally being told they have to treat customers with the tiniest modicum of fairness that even Guido with the baseball bat would consider reasonable, they are all in a snit and "well fine, go ahead and we'll just figure out ways to screw even MORE of you so how DARE anyone regulate us!"

GAD! I don't know why that wonderful invisible hand of the free marketplace (sarcasm intended) isn't creating fairly run credit companies for us to all use alternatively, and let the loansharks go out of business, but it isn't. It absolutely isn't.

They made plenty of money before the deregulations that allowed them to screw us all over - I am not buying this big huge crybaby whinge from them that they will have no choice but to find other ways to rip us off in order to stay solvent. I've heard the arguments and I think they are just ways to rationalize unreasonable and unfair business practises and pure greed.

I've closed all my accounts except for the one with my locally owned credit union Mastercard (which is perhaps fairly close to that invisible hand marketplace option except for some reason people aren't using them - perhaps not everyone can get in them) which is not quite as bad. ~Well, I did keep a Chase account open because I've had it for so many years it might ding my credit rating to close it, but I'm not using it.

I don't know what the solution is, but letting them operate with zero restrictions which is what they'd like, is not it. This notion that businesses will self regulate as it's in their own best interest ~ when will we see that blow up in everyone's face enough times that companies will stop trying to use it for the jeers they get when they do? I guess anything's worth a try though, if the possibility of making more money by being unfair is at stake. I am so not buying the libertarian idea that businesses will figure out the best way if left alone to their own devices. Sooooo not buying it. As evidence: the entire economy for the past 10 years or so.

And I don't want to hear "nobody put a gun to (g)yer head and made you buy a couch you couldn't afford on yer credit card, personal responsibility, blahblahblah." Nobody put a gun to the credit card company, either, forcing them to give credit to people they know damn well shouldn't ever have had it in the first place, and THEY are the ones whose job it is to know better, not the general public. I put the majority of the blame on them.

~boy, that was a rant. I almost feel better now.

Oversea big gun

2009-9 - Now Software Development Engineer (vendor)
Beijing | Full-time | ATC | | employees |
Software Engineer
Mid Career(2+ years experience)
Project: Amalga HIS (Hospital Information System)Description: The system is enterprise solution for hopital information system, including clinic, operation and financeEnvironment: C#, WPFResponsibility: Paticipate in development of system, and responsible for implement of UI and DB operation,Coding and integration, fixing bugs,Features and technical discussions with PM and teammate.
2009-2 - 2009-8 Software Development Engineer (vendor)
Beijing | Full-time | UPG | | employees |
Software Engineer
Mid Career(2+ years experience)
Project: Microsoft Activation AssistanceDescription: A tool for computer refurbishers to activate Windows OSEnvironment: C++Responsibility: Participated in development of client, and implement of client UI and services,Responsible for development and integration of components, Fix bugs, unit test and check-in test,Work with engineers in both USA and China in the development.

Shanghai Baosight Software Co. Ltd

Software | |
2007-2 - 2008-7 Software Developer
Shanghai | Full-time | | | employees |
Software Engineer
Entry Level(less than 2 years experience)
Project: Management Information System for Petrochemical EnterprisesDescription: System integrated with several production platformsEnvironment: C++Responsibility: Participated in development of system, OOD/OOP based on the MVC architecture, Design of use case and UI, and implement for several modules, Continuous integration by CC to execute daily compiling and unit test by CPPUnit, Work on documents and reviews for CMMI-5 process.

Motorola (China) Electronics Ltd.

Telecommunications (Equipment/Operation/Value-Added Service) | |
2005-7 - 2006-4 Software Engineer
Beijing | Intern | | | employees |
Software Engineer
Student
Project: MotoMatchDescription: GSM Network Optimization System, which provided services for global mobile operatorsEnvironment: C, VB .NETResponsibility: Design and development of location software module, which was the key part of the system;C and VB.NET programming for performance test.

Millionaire and Begger

What is it with beggars and Lexuses (Lexi?)

It's interesting that the Straight Dope article refers to some panhandlers treating begging as their job: I was thinking that in order to earn the higher amounts (as opposed to the cost of the next meal/drink/hit) you would need to put some effort into it. Basically you're trading on other people's generosity and/or guilt, so what's the best way to do that? The article mentions that disabled beggars, or those with pets and/or children come off better (which recalls the gangmaster in Slumdog Millionaire, and stories about children being mutilated in order to beg more lucratively).

My point is that it's not necessarily "money for nothing", even if it might be "money for dishonesty".

I was talking to a couple of friends yesterday, and one of them told me that she "never gives money to" a couple who sell The Big Issue in our town because she "tries to discourage beggars". She added that she had seen a woman buy a sandwich for one of the sellers, who had "pulled a face" when it turned out not to have the "right" filling. She was outraged at such a lack of gratitude.

This is all a bit much, to me. Firstly, selling The Big Issue is not "begging". Secondly, although politeness is to be preferred, why must someone grovel to your satisfaction in order to get one sandwich? Maybe she was having a bad day. Maybe you only caught part of the conversation. Maybe you don't know anything about this woman, except that she must spend her time approaching uptight foreigners to buy a not-very-good magazine, in order to make a living.

Maybe I should have had my rant at the time instead of biting my lip and suggesting that we meet up soon and have a coffee, bye.

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AREVA T&D (Guangdong) Switchgear Co. Ltd.

Machine Manufacturing/Heavy Industry | |
2008-2 - Now Planner
Conghua, Guangzhou | Full-time | | | employees |
Planner
Mid Career(2+ years experience)
Currently and solely working as the planner in production, procurement and also contract delivery for over 200 projects.
Directly report to the General Manager.
Cooperate each department in the daily business and help them to build up the operation process to fit in the situation changes.
In charge of the ERP system and manage about 500 pieces of components inventory daily.
Produce planning tools for monthly, weekly planning and material requirement plan in Excel.
Utilise planning tools for building up planning for each department in the daily business.
Full cooperate with all departments both systematically and physically transferring from fully imported material production to localized material production.
In charge of warehouse management with 4 subordinates to operate and monitor all the production material movement within the operation.
Redesign raw material management in order to increase the efficiency of material pick-up process.
Define the better production lot size for production output optimisation in peak season.
At the moment, the company on time delivery is 95% and inventory day is around 15 days.

Peter Hunt’s Bakery Food Ltd. (Bolton, UK)

Consumer Products(FMCG) | |
2007-5 - 2007-10 External Consultant (Internship)
Bolton, United Kingdom | Full-time | | | employees |
Consultant for International Affaire
Student
Responsible to the Managing Director of the company for a waste reduction project.
Identified about £ 200,000 waste (67% of their annual profit) in 5 months production.
Conducted three recommendations to achieve waste reduction objective:
Balancing capacity in the packing line, possible annual gain £ 10,500 for 3 products;
Enhancing the quality check process to ensure product outputs meet client specifications;
Standardising the setups by avoiding un-needed human intervention to save time up to 50%.
Redesigned the company’s waste notice board from Visual Basic format to Excel format for easy maintenance and implementation reasons.
Support and create a business culture about all-staff involvement and continuous improvement.
Raised future projects (e.g. stock management, etc.) to further improve the company’s situation.
The project was rewarded distinction.

Program

Work Responsibility:
a.Be responsible for the new product’s early period development, dispatch the order form and provide the technical support for the product 's produces, so as to completes the order form plan on time.
b.Maintenance customer relations, keep real-time communicates with customer so as to shorter the new product’s development cycle and complete scheduled production quotas smoothly.
c.Participate in company technological innovation, complete the project which is responsible for myself in the technical change, for example, such as new material development and application, data collection and analysis, process craft’s optimal.
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Education

Northeast University

2005-9 - 2008-3 Material process engineering Master | | shenyang
Materials
Main Courses: Structure and Performance of Aluminum- alloy, Metal X-Ray Analysis, Metal Solidification Theory, Material Coriaceous Theory, Mechanics of Materials Multipurpose Optimal Method, Numerical Analysis and so on;
The main research direction is the aluminum silicon alloy molding foundation technical study
College Info
Out of a Total of:people | Rank: | Student Cadre: | Position:
Other Awards:

Northeast University

2001-9 - 2005-7 Material molding and controlling engineering Bachelor | | shenyang
Materials
Main Courses: Introduction to Engineering, Graphing of Engineering, Electrical Engineering, Heat Treatment, Theory of Elastic Mechanics, Basic of Mechanical Designing, Metallurgy Transmission Principium ,Auto-control Theory, PLC Controlling, Compound Materials, Metal Technics, Sheet Metal Forming Technology, Professional English, Rolling Theory and Technics, C Language ,Computer Application Basic and so on;
The graduation project topic is the steel infiltrate through to aluminizes technics study